75000 - Document - Document and Entity Information
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75010 - Statement - Condensed Consolidated Balance Sheets
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75020 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss
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75040 - Statement - Condensed Consolidated Statements of Stockholders' Equity
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75050 - Statement - Condensed Consolidated Statements of Cash Flows
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995457 - Disclosure - Description of Business and Liquidity
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995467 - Disclosure - Summary of Significant Accounting Policies
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995477 - Disclosure - Fair Value Measurements
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995487 - Disclosure - Property and Equipment, Net
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995497 - Disclosure - Accrued Expenses
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995507 - Disclosure - Collaboration, License and Option Agreements
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995517 - Disclosure - Commitments and Contingencies
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995527 - Disclosure - Preferred Stock and Common Stock
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995537 - Disclosure - Stock-Based Compensation
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995547 - Disclosure - Net Loss Per Share
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995557 - Disclosure - Subsequent Events
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995567 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995577 - Disclosure - Fair Value Measurements (Tables)
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995587 - Disclosure - Property and Equipment, Net (Tables)
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995597 - Disclosure - Accrued Expenses (Tables)
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995607 - Disclosure - Collaboration, License and Option Agreements (Tables)
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995617 - Disclosure - Preferred Stock and Common Stock (Tables)
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995627 - Disclosure - Stock-Based Compensation (Tables)
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995637 - Disclosure - Net Loss Per Share (Tables)
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995647 - Disclosure - Description of Business and Liquidity (Details)
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995657 - Disclosure - Summary of Significant Accounting Policies - Segment Information (Details)
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995667 - Disclosure - Fair Value Measurements - Liabilities at fair value on a recurring basis (Details)
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995677 - Disclosure - Fair Value Measurements - Measurement Inputs of Common Stock Warrant Liabilities (Details)
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995687 - Disclosure - Fair Value Measurements - Changes in the fair market value of common stock warrant liabilities classified within the Level 3 fair value hierarchy (Details)
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995697 - Disclosure - Property and Equipment, Net (Details)
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995707 - Disclosure - Accrued Expenses - Summary of Accrued Expenses (Details)
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995717 - Disclosure - Collaboration, License and Option Agreements - Abbvie (Details)
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995727 - Disclosure - Collaboration, License and Option Agreements - Gilead Sciences, Inc. (Details)
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995737 - Disclosure - Collaboration, License and Option Agreements - Summary of Contract Assets and Liabilities (Details)
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995747 - Disclosure - Collaboration, License and Option Agreements - Collaboration Agreement (Details)
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995757 - Disclosure - Commitments and Contingencies (Details)
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995767 - Disclosure - Preferred Stock and Common Stock - Authorized (Details)
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995777 - Disclosure - Preferred Stock and Common Stock - Follow-On Offering (Details)
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995787 - Disclosure - Preferred Stock and Common Stock - Private Placement (Details)
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995797 - Disclosure - Preferred Stock and Common Stock - Sales Agreement and "At-The-Market" Facility (Details)
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995807 - Disclosure - Preferred Stock and Common Stock - Shares Reserved for Future Issuance (Details)
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995817 - Disclosure - Stock-Based Compensation - Stock Incentive Plan (Details)
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995827 - Disclosure - Stock-Based Compensation - 2021 Stock Incentive Plan (Details)
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995837 - Disclosure - Stock-Based Compensation - 2022 Inducement Plan (Details)
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995847 - Disclosure - Stock-Based Compensation - Employee Stock Purchase Plan (Details)
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995857 - Disclosure - Stock-Based Compensation - Stock-based compensation expense (Details)
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995857 - Disclosure - Stock-Based Compensation - Stock-based compensation expense (Details) [Default]
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995867 - Disclosure - Stock-Based Compensation - Stock option activity (Details)
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995877 - Disclosure - Stock-Based Compensation - Stock options, fair value assumptions (Details)
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995887 - Disclosure - Stock-Based Compensation - Stock Option Repricing (Details)
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995897 - Disclosure - Stock-Based Compensation - Stock Options with Performance Conditions (Details)
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995907 - Disclosure - Stock-Based Compensation - Restricted Stock Units (Details)
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995917 - Disclosure - Net Loss Per Share - Prefunded warrants (Details)
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995927 - Disclosure - Net Loss Per Share - Common Stock Equivalents (Details)
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995937 - Disclosure - Subsequent Events (Details)
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999009 - Disclosure - Anchoring
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Represents information pertaining to laboratory equipment.
Laboratory Equipment [Member]
Laboratory equipment
Scenario [Axis]
Share-Based Payment Arrangement, Tranche Four [Member]
Share-based payment arrangement, tranche four.
Tranche 4
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for issuance (in shares)
Shares reserved for future issuance (in shares)
Schedule of Accrued Liabilities [Table Text Block]
Summary of accrued expenses
Preferred Stock, Shares Issued
Preferred stock, shares issued
Measurement Input, Share Price [Member]
Closing price of common stock
Total amount of the incremental compensation expense
Share-Based Payment Arrangement, Plan Modification, Incremental Cost
Commitments and Contingencies.
Commitments and contingencies (Note 7)
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Minimum
Minimum [Member]
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Vesting of restricted common stock (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Debt Conversion, Converted Instrument, Warrants or Options Issued
Fair Value, Recurring [Member]
Recurring basis
Common Stock, Shares, Issued
Common stock, shares issued
Represents the number of anniversaries of grant date on which share-based compensation awards vest.
Share Based Compensation Arrangement By Share Based Payment Award Vesting On Number Of Anniversaries Of Grant Date
Number of equal annual installments in which units vest
Proceeds from issuance of prefunded warrants and common stock warrants in connection with a follow-on offering, net of issuance costs
Proceeds from issuance of prefunded warrants and common stock warrants in connection with a follow-on offering, net of issuance costs
Proceeds from issuance of prefunded warrants and common stock warrants in connection with a follow-on offering, net of issuance costs.
Counterparty Name [Domain]
Repayments of Debt
Repayments of debt principal
The maximum amount of potential contingent consideration receivable under the agreement.
Arrangement Other than Collaborative, Contingent Consideration Receivable
Maximum additional contingent payments receivable
Restricted Stock Units (RSUs) [Member]
Restricted stock units
Unvested restricted stock units
Represents the information pertaining to common stock warrants, classified as liability.
Common Stock Warrants [Member]
Common stock warrants
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Class of warrant or right number of securities called by warrants or rights
Exercises of warrants
The amount of cash allocated to issuance costs for warrants.
Payment of Stock Issuance Costs, Allocated to Warrants
Issuance costs allocated to common stock warrant liabilities
License Agreement Receivable
License agreement receivable.
License agreement receivable
Subsequent Event Type [Domain]
A private placement with Gilead Sciences, Inc.
Private Placement, Gilead Stock Purchase Agreement [Member]
Gilead Stock Purchase Agreement
Property, Plant, and Equipment [Text Block]
Property and Equipment, Net
Represents the annual increase in number of shares of common stock reserved and available for issuance under the plan as a percent of shares of common stock outstanding at beginning of each fiscal year. Excludes additional shares of common determined by board of directors.
Share Based Compensation Arrangement by Share Based Payment Award, Increase in Number of Shares Reserved and Available for issuance, Percentage
Annual increase in number of shares reserved for issuance (as a percent)
Gilead Sciences, Inc.
Gilead Sciences, Inc. [Member]
Gilead Sciences, Inc.
Gilead
Nonoperating Income (Expense)
Total other income, net
Total other income, net
Total other income (expense), net
Represents information pertaining to Series C common stock warrants.
Series C warrant to purchase common stock
Series C common stock warrant liability
Series C
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Represents information pertaining to Series A common stock warrants.
Series A warrant to purchase common stock
Series A common stock warrant liability
Series A
Condensed Consolidated Statements of Operations and Comprehensive Loss
Consolidated Statements of Operations and Comprehensive Loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Forfeited
Disclosure of accounting policy for common stock warrants.
Common Stock Warrants [Policy Text Block]
Common Stock Warrants
No definition available.
Collaboration and License Agreements
Vesting [Axis]
Earnings Per Share, Basic
Net loss per share, basic (in dollars per share)
Earnings Per Share, Basic, Total
Document Period End Date
Accrued Expenses
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Granted (in dollars per share)
Exercise price
Number of securities into which the class of warrant or right purchased during the period may be converted.
Class of Warrant or Right, Warrants Issued
Number of common stock into which the class of warrant or right purchased may be converted
Prefunded warrants in lieu of shares of common stock issued
Common Stock, Shares Authorized
Common stock, shares authorized
Landlord who benefits from the letter of credit held by entity.
Landlord [Member]
Landlord
Condensed Consolidated Statements of Stockholders' Equity
Transfer of finance lease asset to property and equipment
Transfer to Property and Equipment
Value of finance lease asset transferred to property and equipment in noncash transactions.
Warrants and Rights Outstanding, Measurement Input
Measurement input
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
The carrying amount as of the balance sheet date of accrued personnel expenses classified as current.
Accrued Personnel Expenses, Current
Personnel-related
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Outstanding (in dollars)
Assets
Total assets
Title of 12(b) Security
Preferred Stock, Value, Issued
Preferred stock, $0.0001 par value; 5,000,000 shares authorized, no shares issued or outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Unvested awards at end of period (in shares)
Unvested awards at beginning of period (in shares)
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of stock-based compensation expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted (in shares)
Stock options granted
Title and Position [Domain]
Antidilutive Securities, Name [Domain]
Common Stock in Process of Settlement at Period End [Member]
Common stock in process of settlement at period end.
Common stock in process of settlement at period end
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Additional common stock reserved under the plan (in shares)
Proceeds from Issuance of Private Placement
Proceeds from issuance of common stock
Proceeds from issuance of common stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted Average Exercise Price
Interest Paid, Excluding Capitalized Interest, Operating Activity
Cash paid for interest
The cash inflow from the additional capital contribution to the entity, gross.
Proceeds from Issuance of Common Stock, Gross
Gross proceeds from offerings
The fair market value of common stock issued in private placement.
Private Placement, Fair Value
Fair market value of common stock issued (in dollars)
At The Market Offering Programs registered under universal shelf registration statements beginning in 2022 and includes subsequent registration statements including in 2025.
At The Market Offerings [Member]
At-The-Market Offerings
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted-Average Remaining Contractual Term
Outstanding (in years)
Development Milestone Payment Received
Development milestone payment received.
Development milestone payment received from Gilead
Development milestone related payment
Beginning balance
Equity, Attributable to Parent
Ending balance
Total stockholders' equity
Entity Address, Address Line Two
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
2021 Employee Stock Purchase Plan.
Employee Stock Purchase Plan, 2021 [Member]
2021 ESPP
Employee stock purchase plan
Upfront consideration received upon execution of agreement(s). May include, but not limited to collaboration, license, option and/or stock purchase agreements. Also, may include cash payment and equity investment.
License Agreement, Consideration Received
Upfront payment
Upfront payment
Number of new stock and/or warrants issued during the period in private placement.
Issuance of common stock and prefunded warrants, net of issuance costs (in shares)
Common stock and prefunded warrants purchased (in shares)
Issuance of common stock in connection with the exercise of prefunded warrants (in shares)
Earnings Per Share [Text Block]
Net Loss Per Share
Share-based payment arrangement granting right, subject to vesting and other restrictions, to purchase or sell certain number of shares at predetermined price for specified period of time. Also includes share instrument which is convertible to stock or an equivalent amount of cash, after a specified period of time or when specified performance conditions are met.
Share-Based Payment Arrangement, Option and Restricted Stock Units (RSUs) [Member]
Stock options and unvested restricted stock units
Weighted Average [Member]
Weighted average
Number of Reportable Segments
Number of reportable segments
Class of Warrant or Right, Date from which Warrants or Rights Exercisable
Warrants exercisable date
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted Average Grant Date Fair Value
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of financial liabilities at fair value on a recurring basis
Stock, Class of Stock [Table]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation [Abstract]
Reconciliation to amounts within the consolidated balance sheets:
Maximum Stock Offering, Issuance And Sale Amount
Maximum stock offering, issuance and sale amount.
Maximum stock offering, issuance and sale amount
At-the-market offering program registered under the 2022 universal shelf registration statement.
Shelf Registration Statement. 2022 [Member]
At-The-Market Offering, 2022
The gross cash inflow associated with the amount received from holders exercising their stock warrants.
Proceeds from Warrant Exercises, Gross
Proceeds from warrant gross
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested (in dollars per share)
Proceeds from Stock Options Exercised
Proceeds from exercise of stock options
The maximum amount of potential additional private placements and near-term development milestones, prior to transition fee, included in additional contingent consideration receivable under the agreement.
Arrangement Other than Collaborative, Contingent Consideration Receivable, Additional Private Placements and Near-Term Milestones
Maximum additional contingent payments receivable, Near-term development milestones
February Two Thousand And Twenty Six Follow On Offering [Member]
February 2026 follow-on offering.
February 2026 Follow-On Offering
Statistical Measurement [Axis]
The maximum ownership percentage for which counterparty may be deemed beneficial owner under the agreement.
Beneficial Ownership Percentage, Counterparty, Maximum
Maximum beneficial ownership (as a percent)
Represents the number of potential offerings.
Number of Offerings
Number of potential offerings
Deferred Revenue [Abstract]
Deferred revenue
Entity Interactive Data Current
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Expected volatility, maximum (as percentage)
The carrying amount as of the balance sheet date of accrued external research and development classified as current.
Accrued External Research And Development, Current
External research and development
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Stock-Based Compensation
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Agreements
Common Stock, Value, Issued
Common stock, $0.0001 par value; 600,000,000 shares authorized; 6,580,149 shares issued and outstanding at June 30, 2026; 4,530,641 shares issued and outstanding at December 31, 2025
Liabilities
Total liabilities
2022 Inducement Stock Incentive Plan.
Stock Incentive Plan, 2022 [Member]
2022 Inducement Plan
Share-Based Payment Arrangement, Tranche Two [Member]
Tranche 2
Tranche 3
Collaborative Arrangement [Member]
Collaborative Arrangement
Percentage of the company's total outstanding common stock that a warrant holder (including affiliates) may beneficially own before being restricted from exercising additional warrants.
Warrants, Ownership Limitation Percentage
Ownership limitation percentage
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Fair Value, Inputs, Level 3 [Member]
Level 3
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Operating Expenses
Total operating expenses
Total operating expenses
Debt Issuance Costs Incurred During Noncash or Partial Noncash Transaction
Issuance costs included in accounts payable or accrued expenses
Revenues [Abstract]
Revenue
Vesting [Domain]
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Description of Business and Liquidity
Effective Period For Change In Ownership
Effective period for change in ownership
Period during which the holder has to notify the change in ownership to the company to become it effective,
in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Shares Issued, Price Per Share
Purchase price (in dollars per share)
Stock Issued During Period, Shares, New Issues
Issuance of common stock, net of issuance costs (in shares)
Common stock issued (in shares)
Common stock issued and sold (in shares)
Class of Warrant or Right, Outstanding
Warrants outstanding (in shares)
Restricted Cash
Restricted cash
Restricted Cash, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk-free interest rate, maximum (as a percent)
Financial Liabilities Fair Value Disclosure
Total financial liabilities
Represents the Initial Option Program Performance Obligation under the collaboration, license and option agreement and stock purchase agreement.
Collaboration, License and Option Agreement and Stock Purchase Agreement, Initial Option Program Performance Obligation [Member]
Initial Option Program Performance Obligation
Property, Plant, and Equipment, Accumulated Depreciation, Depletion, and Amortization
Less: accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Represents information pertaining to Series B common stock warrants.
Series B warrant to purchase common stock
Series B common stock warrant liability
Series B
Long-Lived Asset, Class [Axis]
Subsequent Events [Text Block]
Subsequent Events
Fair Value Hierarchy and NAV [Axis]
Weighted Average Number of Shares Outstanding, Diluted, Adjustment
Weighted average common shares outstanding, diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted, Adjustment, Total
Property, Plant, and Equipment [Line Items]
Property and Equipment, Net [Line Items]
Risk-free interest rate (as a percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Number of units
Represents number of units sold in the offering.
Number Of Units Sold In The Offering
Payments of stock issuance costs
Payments of issuance costs included in accounts payable or accrued expenses at prior year end
Payments of issuance costs included in accounts payable or accrued expenses at prior year end
Operating Lease, Liability, Current
Operating lease liability, current portion
Lessee, Operating Lease, Existence of Option to Extend [true false]
Option to extend
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Unvested awards at end of period (in dollars per share)
Unvested awards at beginning of period (in dollars per share)
Share Based Payment Arrangement, Tranche Four [Member]
Share Based Payment Arrangement, Tranche Four.
Tranche 4
Liabilities and Equity
Total liabilities and stockholders' equity
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield (as a percent)
Represents information pertaining to collaboration, license and option agreement.
Collaboration, License and Option Agreement [Member]
Collaboration Agreement
Research and Development Expense
Research and development
Research and Development Expense, Total
Lessee, Lease, Description [Table]
Document Fiscal Period Focus
The amount of program nomination fees, preclinical development option extension fees and option fees included in the potential contingent consideration receivable under the agreement.
Arrangement Other than Collaborative, Contingent Consideration Receivable, Fees
Maximum additional contingent payments receivable, Fees
Revenue from Contract with Customer, Product and Service [Extensible Enumeration]
Revenue from Contract with Customer, Product and Service
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of assumptions used in determining fair value of options granted
Title and Position [Axis]
Property, Plant, and Equipment [Table]
Letters of Credit Outstanding, Amount
Letter of credit
Letter of credit for the benefit of landlord
Sale of Stock [Axis]
Transaction price under agreement.
Agreement, Transaction Price
Transaction price
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
(Decrease) increase in cash, cash equivalents and restricted cash
Entity Current Reporting Status
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Exercisable at end of period (in shares)
Number of stock options exercisable
Transaction price related to cash payment under agreement.
Agreement, Transaction Price, Cash Payment
Transaction price, Cash payment
Purchase price per warrant.
Class of Warrant or Right, Purchase Price
Purchase price, warrant (in dollars per share)
Deferred Revenue
Deferred revenue as of end of period
Deferred revenue as of beginning of period
Deferred revenue
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of antidilutive securities excluded from computation of diluted net loss per share
Performance Conditions
Performance Conditions [Member]
Performance Conditions.
Document Transition Report
Commitments and Contingencies
Commitments and Contingencies Disclosure [Abstract]
Subsequent Event [Line Items]
Class of Warrant or Right [Axis]
Liabilities, Current [Abstract]
Current liabilities
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation expense
Represents information pertaining to Series B warrants.
Series B Warrants [Member]
Series B Warrants
Stock-Based Compensation
Stock-Based Compensation [Abstract]
Represents the material right for counterparty's one-time right to substitute the initial target with the backup target for the Initial Option Program under the collaboration, license and option agreement and stock purchase agreement.
Collaboration, License and Option Agreement and Stock Purchase Agreement, Initial Option Program, Target [Member]
Initial Option Program, Material right for counterparty's right to substitute initial target with backup target
Common Stock [Member]
Common Stock
Represents November 2022 Sales Agreement with Cowen and Company LLC under which the Company may issue and sell shares of its common stock. Represents an "At the market" offering.
Cowen Sales Agreement [Member]
At-The-Market Offering, Cowen Sales Agreement
AbbVie Group Holdings.
AbbVie Group Holdings [Member]
AbbVie
Statistical Measurement [Domain]
Nonoperating Income (Expense) [Abstract]
Other income, net
Other income (expense), net
Transaction price related to premium on sale of stock under agreement.
Agreement, Transaction Price, Premium on Sale of Stock
Transaction price, Premium on sale of stock
Equity, Attributable to Parent [Abstract]
Stockholders' equity
Weighted Average Number of Shares Outstanding, Basic
Weighted average common shares outstanding, basic (in shares)
Weighted Average Number of Shares Outstanding, Basic, Total
Stock Incentive Plan 2025
Stock Incentive Plan 2025 [Member]
2025 stock incentive plan.
2025 Plan
Property and Equipment, Net
Assets [Abstract]
ASSETS
Entity Central Index Key
Restructuring Charges
Restructuring
Restructuring Charges, Total
Antidilutive Securities [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Exercisable (in dollars)
Class of Stock [Line Items]
Preferred stock and Common stock
Minimum price per share for equity proceeds to count as non-dilutive capital for the purpose of cancellation.
Warrants, Trigger Price Per Share For Cancellation
Purchase price per share
Current Fiscal Year End Date
Settlement Of Liabilities To Issue Common Stock By Issuing Common Stock
Settlement of liabilities to issue common stock by issuing common stock.
Class of Warrant or Right [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Equity Based Compensation
Document Quarterly Report
Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property
Loss on disposal of property and equipment
Loss on disposal of property and equipment
The amount of transition fee included in the potential contingent consideration receivable under the agreement.
Arrangement Other than Collaborative, Contingent Consideration Receivable, Transition Fee
Maximum additional contingent payments receivable, Transition fee
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Outstanding (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Beginning Balance
Exercise price
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash (used in) provided by operating activities
Entity Incorporation, State or Country Code
Earnings Per Share, Diluted
Net loss per share, diluted (in dollars per share)
Earnings Per Share, Diluted, Total
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value (in dollars per share)
Period over which entity has the right to initiate additional programs under the agreement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.
Additional Option, Period
Additional program initiation period
Net loss
Net loss
Fair Value Adjustment of Warrants
Change in fair value of common stock warrant liabilities
Change in fair value of common stock warrant liabilities
Warrants and Rights Outstanding
Common stock warrant liabilities
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Long-Lived Asset, Class [Domain]
Property and Equipment, Net
Prefunded warrants.
Warrant, Prefunded Warrants [Member]
Prefunded warrants
At-the-market offering program registered under the 2025 universal shelf registration statement.
Shelf Registration Statement. 2025 [Member]
At-The-Market Offering, 2025
Consecutive Trading Days For Warrants Exercisable
Consecutive trading days
Period of consecutive trading days with closing price of minimum $1.50 for the warrant to become exercisable,
in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Equity impact of the value of stock and warrants issued during the period in private placement.
Stock and Warrants Issued During Period, Value, New Issues
Issuance of common stock and prefunded warrants, net of issuance costs
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Net loss and comprehensive loss
Measurement Frequency [Domain]
Scenario [Domain]
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Schedule of changes in the balances of contract liabilities
Equity Components [Axis]
Represents the material right to receive an exclusive license to the Initial Option Program under the collaboration, license and option agreement and stock purchase agreement.
Collaboration, License and Option Agreement and Stock Purchase Agreement, Initial Option Program, Exclusive License [Member]
Initial Option Program, Material right to receive an exclusive license
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities:
Condensed Consolidated Statements of Cash Flows
Fair Value Hierarchy and NAV [Domain]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Exercised (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Fair value of options granted (in dollars per share)
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid and other assets
Per share or per unit of combined offering.
Combined Offering Price Per Share
Combined offering price per share
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Fair Value Measurements
Additional development milestone achieved
Additional Development Milestone Achieved
Additional development milestone achieved.
Represents the number of private placements.
Number of Private Placements
Number of private placements
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
Tranche 3
Share-Based Payment Arrangement, Tranche Three [Member]
Tranche 4
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Total common stock equivalents
Counterparty Name [Axis]
Measurement Input, Expected Term [Member]
Expected term (in years)
Number of Operating Segments
Number of operating segments
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Shares available for future issuance (in shares)
Increase (Decrease) in Deferred Revenue
Deferred revenue
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Class of warrant or right number of securities called by each warrant or right
Result if common stock warrants are exercised in cash at their initial exercise price per warrants.
Common Stock Warrants Exercised at Initial Exercise Price, Scenario [Member]
If common stock warrants are exercised at their initial exercise price of $0.75 per warrant
Segment Reporting, Policy [Policy Text Block]
Segments
Segment Information
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Accrued expenses and other liabilities
Represents March 2025 Sales Agreement with Leerink Partners, LLC under which the Company may issue and sell shares of its common stock. Represents an "At the market" offering.
Leerink Sales Agreement [Member]
At-The-Market Offering, Leerink Sales Agreement
The maximum amount of specified development, regulatory and sales-based milestones included in the potential contingent consideration receivable under the agreement.
Arrangement Other than Collaborative, Contingent Consideration Receivable, Milestones
Maximum additional contingent payments receivable, Milestones
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Forfeited (in dollars per share)
Amount of revenue recognized that was from current period increase in the balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.
Revenue Recognized From Current Period Increase In Contract Liability
Additions
Accrued expenses
Total accrued expenses
Accrued Liabilities, Current
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-Based Compensation
Shares for future issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Outstanding at end of period (in shares)
Outstanding at beginning of period (in shares)
Number of stock options outstanding
Total number of shares of common stock
No definition available.
Share-based Compensation Arrangement by Share-based Payment Award, Options, Aggregate Intrinsic Value [Abstract]
Aggregate Intrinsic Value
Document Type
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities:
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Lessee, Lease, Description [Line Items]
Leases
Outstanding stock options
Subsequent Event
Subsequent Event [Member]
Operating Income (Loss)
Loss from operations
Loss from operations
Risk free interest rate
Measurement Input, Risk Free Interest Rate [Member]
The premium of common stock issued in private placement.
Private Placement, Premium
Premium of common stock issued (in dollars)
2021 Stock Incentive Plan.
Stock Incentive Plan 2021 [Member]
2021 Plan
Securities Act File Number
Proceeds from Issuance of Prefunded Warrants in Connection with Follow-on Offering, Net of Issuance Costs
Proceeds from issuance of prefunded warrants in connection with a follow-on offering, net of issuance costs.
Proceeds from issuance of prefunded warrants in connection with a follow-on offering, net of issuance costs
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Vesting of restricted common stock
Measurement Input, Exercise Price [Member]
Warrant exercise price
A private placement with certain accredited investors and issuance to Gilead.
Gilead and Private Placement, Certain Accredited Investors [Member]
Gilead and Certain Accredited Investors in Private Placements
Term of option to extend under the operating lease.
Lessee Operating Lease, Extended Lease Term
Term of option to extend
Location, Statement of Income, Balance [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate, minimum (as a percent)
Retained Earnings [Member]
Accumulated Deficit
Represents the number of promises under agreement.
Agreement, Number Of Promises
Number of promises
Entity Registrant Name
Summary of Significant Accounting Policies
Depreciation
Depreciation
Depreciation, Total
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Entity Address, Address Line One
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Weighted Average Remaining Contractual Term (In years)
Purchase price of warrant
Warrants Purchase Price Per Share
Warrants purchase price per share.
F. Hoffmann-La Roche Ltd.
F. Hoffmann-La Roche Ltd. [Member]
F. Hoffmann-La Roche Ltd.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercise of stock options (in shares)
Exercised (in shares)
Exercise of stock options (in shares)
2020 Plan, 2021 Plan and 2022 Inducement Plan
2021 and 2020 Stock Incentive Plan and 2022 Inducement Plan.
Stock Incentive Plans, 2021 Plan and 2020 Plan, And 2022 Inducement Plan [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Exercisable at end of period (in dollars per share)
Weighted-average exercise price per share of options exercisable
Assets, Current
Total current assets
Furniture and Fixtures [Member]
Furniture and fixtures
Represents increase in number of shares reserved and available for issuance at beginning of each fiscal year under the plan.
Share Based Compensation Arrangement by Share Based Payment Award, Increase in Number of Shares Reserved and Available for issuance, Number
Annual increase in number of shares reserved and available for issuance (in shares)
Fair Value, Recurring and Nonrecurring [Table]
Supplemental Cash Flow Information [Abstract]
Supplemental cash flow disclosure:
Entity Small Business
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation expense
Represents information pertaining to Clinical Supply Agreement, a collaborative arrangement for revenue-generating activity or operations.
Clinical Supply Agreement [Member]
Clinical Supply Agreement
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited (in dollars per share)
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stockholders' Deficit
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Net Loss Per Share
Net Loss Per Share
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of stock option activity
A private placement with certain accredited investors initiated in March 2024. The private placement closed on April 2, 2024.
Private Placement, Certain Accredited Investors, March 2024 [Member]
Private Placement
follow-on public offering
Follow-On Public Offering [Member]
Follow-on public offering.
Plan Name [Axis]
Subsequent Event Type [Axis]
Preferred Stock and Common Stock
Equity [Text Block]
Preferred Stock and Common Stock
Measurement Frequency [Axis]
Represents information pertaining to collaboration, license and option agreement and stock purchase agreement.
Collaboration, License and Option Agreement and Stock Purchase Agreement [Member]
Collaboration and Stock Purchase Agreement
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities:
Cash payment portion of upfront consideration received upon execution of agreement. May include, but not limited to collaboration, license, option and/or stock purchase agreements.
License Agreement, Consideration Received, Cash
Upfront payment, cash
Collaboration and license agreement receivable
Collaboration and license agreement receivable.
Substantial Doubt about Going Concern, within One Year [true false]
Substantial doubt about going concern within one year
Accrued Expenses
Accrued Expenses
Entity Tax Identification Number
Equity Component [Domain]
Entity Address, City or Town
Measurement Input Type [Domain]
Capital Expenditures Incurred but Not yet Paid
Capital expenditures included in accounts payable or accrued expenses
Contract with customer liability additions
Contract with customer liability additions.
Additions
Stock Issued During Period, Value, New Issues
Issuance of common stock, net of issuance costs
Restricted Cash, Noncurrent
Restricted cash
Restricted Cash, Noncurrent, Total
Entity Common Stock, Shares Outstanding
Represents the right to receive additional services related to the Initial Option Program under the collaboration, license and option agreement and stock purchase agreement.
Collaboration, License and Option Agreement and Stock Purchase Agreement, Initial Option Program, Additional Services [Member]
Initial Option Program, Right to receive additional services
Represents information pertaining to Series C warrants.
Series C Warrants [Member]
Series C Warrants
Contract with Customer, Asset, Cumulative Catch-up Adjustment to Revenue, Modification of Contract
Cumulative catch-up of revenue
Antidilutive Security, Excluded EPS Calculation [Table]
Maximum value of securities authorized to be sold in offering. May include, but not limited to common stock, preferred stock, debt securities, units and warrant.
Securities Offering, Value, Securities Authorized to be Sold
Maximum amount of securities available
Lessee, Operating Lease, Option to Extend
Option to extend
Statement [Table]
Shares Issued, Shares, Share-Based Payment Arrangement, before Forfeiture
Shares issued under plan (in shares)
Deferred Revenue, Current
Deferred revenue, current portion
Deferred Revenue, Current, Total
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Total stock-based compensation expense
Entity Shell Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash used in investing activities
Statement [Line Items]
Statement
Deferred Revenue, Noncurrent
Deferred revenue, net of current portion
Deferred Revenue, Noncurrent, Total
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Measurements
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested (in shares)
Maximum [Member]
Maximum
Sale of Stock [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Canceled in Period
Share-based compensation arrangement by share-based payment award, options, canceled in period.
Canceled (in shares)
Construction in process
Construction in Progress [Member]
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Summary of restricted stock unit activity
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Subsequent Events [Abstract]
Fair Value, Liability, Recurring Basis, Unobservable Input Reconciliation, Gain (Loss), Statement of Income or Comprehensive Income [Extensible Enumeration]
Fair Value, Liability, Recurring Basis, Unobservable Input Reconciliation, Gain (Loss), Statement of Income or Comprehensive Income
Area leased under the operating lease by the lessee.
Lessee Operating Lease, Area Leased
Area leased (in square feet)
Assets, Current [Abstract]
Current assets
Accrued Professional Fees, Current
Professional and consulting fees
Warrants expired
Warrants Expired
Warrants Expired
Percentageofcumulativeincreaseinsharesavailableforissuance
Percentageofcumulativeincreaseinsharesavailableforissuance
Percentage of cumulative increase in shares available for issuance
Document Fiscal Year Focus
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Forecast [Member]
Scenario Forecast
Entity Ex Transition Period
Operating Lease, Liability, Noncurrent
Operating lease liability, net of current portion
Contract with Customer, Liability, Revenue Recognized
Collaboration and license revenue recognized
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Change in fair value of common stock warrant liabilities
Issuance of Common Stock to Settle Liabilities to Issue Common Stock
Issuance of common stock to settle the liabilities to issue common stock.
Issuance of common stock to settle the liabilities to issue common stock
Stock Options with Performance Conditions [Member]
Stock options with performance conditions.
Stock Options with Performance Conditions
Represents the number of additional programs.
Number of Additional Programs
Number of additional programs
Other Accrued Liabilities, Current
Other
Represents information pertaining to License Agreement and Stock Purchase Agreement considered one contract under ASC 606.
License Agreement and Stock Purchase Agreement [Member]
License and Stock Purchase Agreement
Security Exchange Name
Measurement Input Type [Axis]
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements Not Yet Adopted
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price, warrants (in dollars per share)
Entity Address, State or Province
Vesting description
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted-average period for unrecognized compensation expense to be recognized
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Options Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Expected volatility, minimum (as percentage)
Operating Lease, Right-of-Use Asset
Operating lease right-of-use asset
Amendment Flag
Represents the number of programs.
Number of Programs
Number of programs
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Represents the Collaboration Program Performance Obligation under the collaboration, license and option agreement and stock purchase agreement.
Collaboration, License and Option Agreement and Stock Purchase Agreement, Collaboration Program Performance Obligation [Member]
Collaboration Program Performance Obligation
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Other Nonoperating Income (Expense)
Other income, net
Other Nonoperating Income (Expense), Total
Other income, net
Other income (expense), net
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Cash, cash equivalents and restricted cash, end of period
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Restricted cash
Stock Option Repricing [Member]
Stock option repricing.
Stock Option Repricing
City Area Code
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock under employee stock purchase plan
The number of warrants cancelled for each dollar of non-dilutive capital received by the Company prior to the exercise or expiration of the warrants.
Warrants Cancellation Ratio, Per Dollar of Non-Dilutive Capital Received
Warrants cancellation ratio
Description of Business, Liquidity and Going Concern
Description of Business and Liquidity
Proceeds from Issuance of Common Stock
Net proceeds from offerings
Proceeds from issuance of common stock
The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement, gross.
Proceeds from Issuance of Private Placement, Gross
Gross proceeds from issuance of private placement
Represents information pertaining to Series A warrants.
SeriesA Warrants [Member]
Series A Warrants
Operating Expenses [Abstract]
Operating expenses
Issuance of common stock to settle liabilities to issue common stock (in shares)
Issuance of Common Stock to Settle Liabilities to Issue Common Stock Shares
Issuance of common stock to settle liabilities to issue common stock shares.
Minimum closing price of the company's common stock that must be met or exceeded for five consecutive trading days for the warrant to become exercisable.
Warrants, Trigger Price Per Share
Warrants, trigger price per share
Warrants cancellation price per share
Warrants Cancellation Price Per Share
Warrants cancellation price per share.
Common Stock, Par or Stated Value Per Share
Common stock, par value (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted-Average Remaining Contractual Term
Exercisable at end of period (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Eligible to vest
Liabilities, Current
Total current liabilities
Total current liabilities
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of non-cash activities:
Leasehold Improvements [Member]
Leasehold improvements
Leasehold improvements
Property, Plant, and Equipment, before Accumulated Depreciation, Depletion, and Amortization
Property and equipment
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Trading Symbol
June Two Thousand And Twenty Five Follow On Offering [Member]
June 2025 Follow On Offering.
June 2025 Follow-On Offering
Property, Plant, and Equipment [Table Text Block]
Summary of property and equipment, net
Subsequent Event [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted (in shares)
Entity Emerging Growth Company
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Number of warrants exercised during the period.
Warrants Exercised
Warrants exercised (in shares)
Plan Name [Domain]
Share-Based Payment Arrangement, Tranche One [Member]
Tranche 1
Tranche 2
Research and development expense, net. Reduction in research expense represents receipt of cost-sharing payments.
Research and Development Expense, Net
Reduction in research and development expenses
Executive Officer [Member]
Executive Team
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock under employee stock purchase plan (in shares)
Measurement Input, Price Volatility [Member]
Expected volatility
Maximum value of shares authorized to be sold in stock offering.
Stock Offering, Value, Shares Authorized to be Sold
Maximum amount of shares available
Document and Entity Information [Abstract]
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Schedule of measurement inputs of common stock warrant liabilities
Total shares per tranche
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Per Tranche
Share-based compensation arrangement by share-based payment award, options, grants in period, gross per tranche.
Tabular disclosure of aggregate number of common shares reserved for future issuance.
Schedule of Shares Reserved for Future Issuance [Table Text Block]
Schedule of shares reserved for future issuance
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentrations of Credit Risk
Concentrations of Credit Risk and Significant Suppliers
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense, Total
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Schedule of change fair value of the liabilities, measured with Level 3
Additional Paid in Capital
Additional paid-in capital
Additional Paid in Capital, Total
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Fair Value Measurements
Cash and Cash Equivalent
Cash and cash equivalents
Cash and Cash Equivalent, Total
Collaboration, License and Option Agreements [Text Block]
The entire disclosure for collaboration, license and option agreements.
Collaboration, License and Option Agreements
Represents information pertaining to Series B warrants and Series C warrants.
Series B Warrants and Series C Warrants [Member]
Series B Warrants and Series C Warrants
Employee Stock [Member]
Employee stock purchase plan
Unvested employee stock purchase plan shares
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Ending balance
Beginning balance
Proceeds from Stock Plans
Proceeds from issuance of common stock under employee stock purchase plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Forfeited (in shares)
Entity Filer Category
Liabilities to Issue Common Stock
Liabilities to issue common stock.
Liabilities to issue common stock
Warrants not exercised and expired
Warrants Unexercised and Expired
Warrants unexercised and expired.
All other employees [Member]
All other employees.
All Other Employees
Increase (Decrease) in Accounts Receivable
Collaboration and license agreement receivable
Collaboration and license agreement receivable
Property, Plant, and Equipment, after Accumulated Depreciation, Depletion, and Amortization
Property and equipment, net
Property and equipment, net
A private placement with AbbVie Inc.
Private Placement, AbbVie Inc. Stock Purchase Agreement [Member]
AbbVie Stock Purchase Agreement
Revenue from Contract with Customer, Excluding Assessed Tax
Revenue
Total revenue
Shares, Outstanding
Ending balance (in shares)
Beginning balance (in shares)
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Issuances
Initial fair value of common stock warrant liabilities
Represents information pertaining to prefunded warrants.
Prefunded Warrants [Member]
Prefunded warrants
Entity Address, Postal Zip Code
Issuance of stock shares following the company's initial public offering.
Follow-On Offering [Member]
Follow-on offering
Condensed Consolidated Balance Sheets
Finance Lease, Principal Payments
Payments of finance lease
Financing cash flows from finance leases
Local Phone Number
Collaboration And License Member
Collaboration And License Member